Figure 3.

Influence of Place Cell Stimulation on Running Behavior

(A) Place cell population average ΔF/F across virtual space from an example Start-PC stimulation session, top is baseline epoch and bottom is stimulation epoch, and neurons in both plots are ordered and normalized by baseline peak.

(B) Spatial trajectory data from the last 5 min of an example baseline epoch and first 5 min of the subsequent Start-PC stimulation epoch; green circles denote correct trials, red circles denote incorrect trials, and orange area depicts the reward zone.

(C) Change in spatial occupancy from baseline across space during Reward-PC and Start-PC stimulation epochs, averaged within and then across animals (n = 7 mice).

(D) Summary of the within mouse change in occupancy beyond the reward zone caused by Reward-PC and Start-PC stimulation (n = 7 mice).

(E) Change in the number of deceleration events from baseline across space during Reward-PC and Start-PC stimulation epochs.

(F) Summary of the within mouse change in deceleration events before the stimulation point caused by Reward-PC and Start-PC stimulation (n = 7 mice).

(G) Change in the number of deceleration events from baseline during Reward-PC stimulation epochs relative to the stimulation point, 3 trial blocks in each panel with a sliding window approach, averaged within and then across animals (n = 7 mice); dashed orange lines mark the peak of the increase in deceleration events, solid red lines marks the stimulation point.

(H) Peak location of the increase in deceleration events across trial blocks (Pearson’s correlation).

(I) Chance distribution of correlation R² values generated from 100,000 shuffles of trial block order and observed value from the data in (H) (red line).

(J) Same as in (I) but for the slope of a linear fit.

^∗p < 0.05, ^∗∗∗p < 0.001; all error bars show SEM.

See also Figure S3.