Figure 5.

Stimulation-Driven Remapping Influences Spatial Behavior

(A) Trial-wise normalized ΔF/F heat plots for 4 neurons from baseline, Start-PC, Reward-PC, and Non-PC stimulation sessions; the track is cropped at 180 cm due to low occupancy data beyond the reward zone. Only trials where the mouse traversed at least 150 cm of the track are shown.

(B) Single-cell correlation values for average pre-post epoch place maps across sessions and split by baseline place field location.

(C) Distributions of place field center-of-mass for pre- and post-epochs during no-stimulation and place cell stimulation sessions. Note the shift toward the center of the track after stimulation of the place cell network.

(D) Pre-post place field center-of-mass distribution peak differences across session type.

(E) Center of mass shifts for all Start-PCs and Reward-PCs during no-stimulation, Start-PC stimulation, and Reward-PC stimulation sessions.

(F) Average single-cell center-of-mass shifts for Start-PCs and Reward-PCs across session types.

(G) Pre-post change in lick distribution across space averaged across sessions.

(H) Summary of the change in lick rate within the reward area between pre- and post-epochs for different session types, licking was decreased following Reward-PC stimulation.

(I) Correlation between the change in reward-zone lick rate and the shift in place cell distribution peak across all session types.

^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001; all error bars show SEM. See also Figure S5.