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Iron(II)-based detection and treatment of mice infected with Gram-negative pathogens. A. Scheme illustrating bioluminescence imaging of Fe2+ at sites of infection using ICL-1 in FVB-Luc+ mice infected with A. baumannii. B. Scheme illustrating Fe2+ targeted therapy using the caged LpxC inhibitor TRX-PF508 in BALB/c mice bearing an acute lung infection with the Gram-negative pathogen P. aeruginosa.
