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. 2020 Sep 18;7(6):3983–3995. doi: 10.1002/ehf2.12996

Figure 3.

Figure 3

Finerenone treatment improves extensor digitorum longus (EDL) force generation during a contraction induced injury protocol. (A) EDL forces measured throughout the eccentric contraction (Ecc) protocol as a percentage of force generation during the first eccentric contraction (Ecc1). Bonferroni post‐hoc test was use to find significant differences throughout the eccentric contractions. Means that do not share a letter are significantly different from each other. (B–D) Measurements of EDL contractile force after Ecc2, Ecc5, and after a rest period (Ecc6) expressed as a percentage of force generated during Ecc1. The finerenone‐treated group has significantly higher relative EDL contractile force compared with untreated Het mice after Ecc2 (P = 0.0186), Ecc5 (P = 0.0075), and after the rest period (P = 0.0043, Dunnett's post‐hoc test). The same test was used to determine significant differences between wild‐type (C57) and untreated Het mice after Ecc2 (P = 0.0019), Ecc5 (P < 0.0001), and after the rest period (P < 0.0001). Treatment groups: C57 (n = 17), untreated (n = 18), Finerenone (n = 18). Statistical significance: *P ≤ 0.05, **P ≤ 0.01, and ****P ≤ 0.0001.