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SPR sensograms showing the mode of binding of (A) cobicistat, (B) cangrelor, and (C) denufosol to the immobilized Mpro on the CM-5 chip. Cobicistat was found to show the best KD value of 2.1 μM followed by 0.7 mM for cangrelor and 1.44 mM for denufosol.
