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. 2020 Dec;128:249–257. doi: 10.1016/j.molimm.2020.10.018

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© 2020 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 4 — Dapk2 interacts with Raptor to dampen TCR-induced mTORC1 signaling. (A-B) Flag-tagged Dapk2 was immunoprecipitated from lysates of transduced HEK293 T cells that co-express HA-tagged Raptor (A) or transduced Jurkat T cells (B). The association between Dapk2 and Raptor were determined by western blot. (C) Time course analysis of S6K1 (T389) and Akt (T308) phosphorylation after CD3 cross-linking of WT or KO CD4⁺ T cells. Data are representative of two (A, B) or three (C) independent experiments.