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. Author manuscript; available in PMC: 2020 Dec 22.
Published in final edited form as: Science. 2020 Jan 31;367(6477):586–590. doi: 10.1126/science.aax5863

Fig. 2. Myeloid progenitors are leukemia-initiating cells in Npm1c AML.

Fig. 2.

(A) Experimental overview of secondary transplantation of long-term engrafted mutant GMPs. (B to D) Kaplan-Meyer survival analysis (B), representative spleen images (C), and spleen weights (D) of secondary transplants of MIG-CRENpm1c/Dnmt3a LT-GMPs or LSK-derived cells and MxCreNpm1c LT-GMPs (n ≥ 4 mice per group). One-way analysis of variance (ANOVA) was performed. Error bars indicate mean ± SD. *P < 0.05; ns, not significant. (E) Top 10 up-regulated genes in MIG-CRENpm1c/Dnmt3a mutant leukemic GMPs compared with WT GMPs (n = 3 mice per group).