Table 1.
Baseline characteristics of randomized subjects in the DAPT study, with versus without complex coronary anatomy.*
| Measure | Complex Anatomy (N=3730 Subjects) | Non-Complex Anatomy (N=7824 Subjects) | P-value |
|---|---|---|---|
| Age (years) | 60.4±10.5 (3730) | 61.8±10.2 (7824) | <.001 |
| Male | 78.7% (2934/3730) | 73.2% (5727/7824) | <.001 |
| Hispanic or Latino | 3.8% (137/3654) | 3.5% (267/7687) | 0.48 |
| Race – Non-white | 7.8% (286/3653) | 9.0% (694/7688) | 0.04 |
| Body mass index (kg/m2) | 30.2±5.6 (3705) | 30.5±5.8 (7752) | 0.003 |
| Diabetes mellitus | 26.4% (982/3717) | 30.5% (2376/7796) | <.001 |
| Hypertension | 67.8% (2517/3714) | 75.9% (5929/7808) | <.001 |
| Current cigarette smoker or within past year | 31.6% (1165/3689) | 25.5% (1962/7697) | <.001 |
| Stroke/Transient ischemic attack | 3.4% (127/3723) | 3.4% (267/7810) | 1.00 |
| Congestive heart failure | 4.3% (159/3717) | 4.5% (354/7804) | 0.56 |
| Left ventricular ejection fraction < 30% | 2.4% (82/3478) | 1.7% (121/7157) | 0.02 |
| Renal insufficiency/failure | 4.3% (160/3719) | 3.9% (304/7801) | 0.31 |
| Peripheral arterial disease | 5.7% (212/3730) | 5.5% (428/7824) | 0.63 |
| Previous percutaneous coronary intervention | 28.4% (1057/3717) | 29.0% (2262/7802) | 0.55 |
| Coronary artery bypass graft | 15.0% (556/3719) | 8.7% (682/7816) | <.001 |
| Atrial fibrillation | 2.7% (99/3717) | 3.0% (230/7798) | 0.40 |
| Previous MI | 22.6% (832/3684) | 20.7% (1593/7709) | 0.02 |
| History of cancer | 9.4% (348/3699) | 9.0% (702/7774) | 0.51 |
| Indication for Index Procedure | |||
| STEMI | 26.3% (979/3730) | 8.9% (693/7824) | <.001 |
| Non-STEMI | 19.0% (711/3730) | 14.9% (1167/7824) | <.001 |
| Stable Angina | 27.2% (1014/3730) | 39.7% (3102/7824) | <.001 |
| Unstable Angina** | 14.0% (521/3730) | 16.5% (1288/7824) | <.001 |
| Other | 13.5% (505/3730) | 20.1% (1574/7824) | <.001 |
| Number of Treated Vessels (per patient) | <.001 | ||
| 1 | 87.8% (3261/3716) | 90.8% (7099/7821) | |
| 2 | 11.0% (408/3716) | 9.2% (721/7821) | |
| 3 | 1.3% (47/3716) | 0.0% (1/7821) | |
| Mean±SD (N) | 1.1±0.4 (3716) | 1.1±0.3 (7821) | <.001 |
| Number of Stents (per patient) | 1.7±0.9 (3730) | 1.3±0.6 (7824) | <.001 |
| Prasugrel | 34.4% (1284/3730) | 30.6% (2393/7824) | <.001 |
| Clopidogrel | 65.6% (2446/3730) | 69.4% (5431/7824) | |
| Anatomic Complexity Characteristics | |||
| Unprotected left main stented | 1.2% (43/3730) | 0.0% (0/7824) | <.001 |
| >2 lesions per vessel | 5.5% (204/3730) | 0.0% (0/7824) | <.001 |
| Lesion length ≥30 mm | 29.9% (1115/3729) | 0.0% (0/7824) | <.001 |
| Bifurcation lesion with side branch ≥2.5 mm stented | 19.3% (719/3728) | 0.0% (0/7824) | <.001 |
| Vein bypass graft stented | 8.6% (322/3730) | 0.0% (0/7824) | <.001 |
| Thrombus-containing lesion | 43.2% (1532/3550) | 0.0% (0/7192) | <.001 |
| Prior brachytherapy | 0.8% (28/3716) | 0.0% (0/7824) | <.001 |
| Stent Type | <.001 | ||
| Sirolimus-Eluting | 9.6% (357/3730) | 9.7% (758/7824) | |
| Zotarolimus-Eluting | 11.1% (414/3730) | 10.8% (848/7824) | |
| Paclitaxel-Eluting | 24.5% (915/3730) | 22.3% (1747/7824) | |
| Everolimus-Eluting | 35.1% (1308/3730) | 42.4% (3316/7824) | |
| >1 DES type | 2.6% (95/3730) | 1.5% (115/7824) | |
| BMS | 17.2% (641/3730) | 13.3% (1040/7824) | |
| Stent Diameter <3 mm | 43.1% (1606/3730) | 43.4% (3399/7824) | 0.70 |
| Stent Diameter ≥3mm | 56.9% (2124/3730) | 56.6% (4425/7824) | |
| Total stent lengths (mm) | 35.3±20.8 (3730) | 23.1±12.1 (7824) | <.001 |
| BMS | 17.2% (641/3730) | 13.3% (1040/7824) | <.001 |
| DES | 82.8% (3089/3730) | 86.7% (6784/7824) | |
| Treated Vessel | |||
| Left Main | 1.5% (56/3730) | 0.7% (55/7822) | <.001 |
| Left anterior descending | 41.7% (1554/3730) | 46.0% (3596/7822) | <.001 |
| Right coronary artery | 39.7% (1480/3730) | 34.2% (2677/7822) | <.001 |
| Circumflex | 22.3% (833/3730) | 28.0% (2188/7822) | <.001 |
| Venous graft | 8.6% (320/3730) | 0.0% (0/7824) | <.001 |
| Arterial graft | 0.4% (15/3730) | 0.6% (47/7824) | 0.220 |
Abbreviations: BMS, bare metal stent; DES, drug-eluting stent; MI, myocardial infarction; STEMI, ST-elevation myocardial infarction.
*
Values are % (N/D), except as noted. Plus–minus values are means ±SD.
**
This category included unstable angina without reported elevation of cardiac enzymes.