Table II.

Platelet biomarkers in COVID-19 patients

		T1	T2	T3	p
AA-induced max PA, %	all	39 [30–54]	37 [32–45]	39 [35–46]	0.824
	non-ICU	31.5 [28.5–47.5]	28 [25–41]	35 [30.5–44]
	ICU	41 [33–56]	38 [33]	39 [35–46]
ADP 5-induced max PA, %	all	44 [36–53]	46 [40–51]	43 [37–48]	0.321
	non-ICU	38 [32–46]	38 [33–52]	39.5 [35–43]
	ICU	48 [40–55]	48 [42–50]	43 [38–48]
ADP 20-induced max PA, %	all	58 [45–65]	60 [48–64]	52 [47–58]	0.290
	non-ICU	48 [42–63]	47 [41–64]	50 [44–53.5]
	ICU	61 [54–65]	61 [54–65]	56 [47–59]
TRAP-induced max PA, %	all	57.5 [46–76]	60.5 [50–71]	54 [48–60]	0.497
	non-ICU	51 [43–58]	51 [43–58]	46.5 [44–58.5]
	ICU	66 [47–78]	62 [54–71]	56 [51–64]
P-selectin, (ng/ml)	all	74 [50–113]	69.6 [40.5–104.1]	63.2 [39.8–87.7]	0.044
	non-ICU	50.1 [37.8–78.8]	52.6 [31.2–68.4]	37.9 [26.8–80.4]
	ICU	81.2 [55.2–134.9]	78.8 [58.1–122.8]	65.8 [45.1–92.1]
sCD40L, (pg/ml)	all	398 [167–859.6]	340.6 [76.1–642.8]	164.1 [79.7–556.9]	0.039
	non-ICU	231.1 [97.4–415.5]	65.9 [23.4–208.1]	72.9 [46.3–164]
	ICU	432.4 [264.9–1008.5]	463.1 [108.8–1028.9]	192.3 [87.8–756.9]

The values are reported as median and interquartile range. The p-value is for the trend from T1 to T3.

ICU: intensive care unit. AA: arachidonic acid. ADP: adenosine diphosphate. TRAP: thrombin receptor agonist peptide. sCD40L: soluble CD40 ligand.