. 2020 Sep 1;7(6):4384–4389. doi: 10.1002/ehf2.12934

TABLE 2.

Genetic associations of candidate variants in all‐cause HF, HF‐REF, and idiopathic HF

Ref	SNP	Gene	Chr	Position ^a	Ref allele	Effect allele	EAF controls (n = 1529)	All HF (n = 799) ^b			HF‐REF (n = 417)			Idiopathic dilated cardiomyopathy (n = 104)
Ref	SNP	Gene	Chr	Position ^a	Ref allele	Effect allele	EAF controls (n = 1529)	EAF	OR (95% CI)	P	EAF	OR (95% CI)	P	EAF	OR (95% CI)	P
Esslinger et al. ³	rs848210	SPEN	1	16 259 813	G	A	0.424	0.437	1.06 (0.92–1.21)	0.409	0.44	1.04 (0.88–1.24)	0.625	0.457	1.14 (0.86–1.51)	0.377
Esslinger et al. ³	rs10927875	ZBTB17	1	16 299 312	C	T	0.319	0.299	0.96 (0.83–1.11)	0.562	0.284	0.90 (0.75–1.08)	0.260	0.298	0.94 (0.69–1.28)	0.690
Cappola et al. ¹⁴	rs1739843	HSPB7	1	16 343 254	C	T	0.394	0.369	0.88 (0.77–1.01)	0.077	0.344	0.81 (0.68–0.97)	0.020	0.327	0.78 (0.58–1.06)	0.107
Cappola et al. ¹⁵	rs10927887	CLCNKA	1	16 351 275	G	A	0.427	0.401	0.89 (0.77–1.02)	0.091	0.373	0.82 (0.69–0.97)	0.024	0.35	0.77 (0.57–1.03)	0.082
Esslinger et al. ³	rs3829746	TTN	2	179 427 536	T	C	0.235	0.243	1.03 (0.88–1.21)	0.713	0.230	0.97 (0.79–1.19)	0.764	0.207	0.85 (0.59–1.21)	0.371
Cappola et al. ¹⁴	rs6787362	FRMD4B	3	69 227 379	A	G	0.114	0.110	0.94 (0.76–1.16)	0.555	0.113	1.00 (0.76–1.31)	0.988	0.144	1.32 (0.87–2.00)	0.193
Esslinger et al. ³	s13107325	SLC39A8	4	103 188 709	C	T	0.077	0.098	1.28 (1.01–1.63)	0.044	0.103	1.26 (0.93–1.71)	0.129	0.115	1.43 (0.90–2.29)	0.134
Esslinger et al. ³	rs4712056	MLIP	6	53 989 526	A	G	0.369	0.388	1.13 (0.98–1.31)	0.091	0.399	1.21 (1.01–1.46)	0.038	0.423	1.33 (0.98–1.80)	0.066
Esslingeret al. ³	rs2291569	FLNC	7	128 488 734	G	A	0.080	0.093	1.08 (0.84–1.37)	0.560	0.098	1.20 (0.88–1.62)	0.253	0.067	0.77 (0.43–1.39)	0.386
Villard et al. ⁸	rs2234962	BAG3	10	121 429 633	T	C	0.201	0.185	0.97 (0.82–1.15)	0.755	0.167	0.88 (0.70–1.10)	0.257	0.087	0.42 (0.25–0.68)	0.0005
Esslinger et al. ³	rs3188055	INPP5F	10	121 586 882	A	G	0.342	0.372	1.12 (0.96–1.29)	0.141	0.369	1.09 (0.91–1.31)	0.34	0.380	1.17 (0.87–1.58)	0.306
Esslingeret al. ³	rs1051168	NMB	15	85 200 520	G	T	0.292	0.309	1.11 (0.95–1.28)	0.191	0.315	1.16 (0.96–1.41)	0.116	0.346	1.25 (0.92–1.70)	0.153
Esslinger et al. ³	rs3803403 ^c	ALPK3	15	85 383 145	C	G	0.286	0.320	1.20 (1.03–1.39)	0.016	0.325	1.26 (1.04–1.51)	0.017	0.363	1.38 (1.02–1.86)	0.038
Esslinger et al. ³	rs2303510	FHOD3	18	34 324 091	G	A	0.309	0.320	1.04 (0.90–1.20)	0.600	0.313	1.00 (0.84–1.21)	0.969	0.279	0.85 (0.62–1.17)	0.315

Chr, chromosome; CI, confidence interval; EAF, effect allele frequency; HF, heart failure; HF‐REF, HF with a reduced left ventricular ejection fraction; OR, odds ratio; Ref, reference; SNP, single nucleotide polymorphism.

Association in same direction as previously reported and P < 0.0045 (yellow highlight) or P = 0.05–0.0046 (blue highlight).

^{^a}

Position of variants from NCBI Build 37 assembly.

^{^b}

For the ‘all HF’, all patients with a history of HF were included, even if they had since undergone heart transplantation. Patients who had undergone heart transplant (n = 53) were excluded from all other sub‐type analyses. All analyses were performed using a logistic regression controlling for age, sex, and 10 principal components.

^{^c}

Imputed variant.