Table 2.
Clinical Outcomes of Pharyngeal and Rectal Infections Treated With 360 mg Intramuscular Gentamicin, Gentamicin Minimum Inhibitory Concentration (MIC), Peak Serum Concentration (Cmax), Weight-Based Dosing, and Cmax/MIC Ratio
| Study ID | Pharyngeal Treatment Outcome | Rectal Treatment Outcome | Gentamicin MIC, µg/mL | Cmax, µg/mL | Weight-based Dosing, mg/kg | Cmax/MIC Ratio |
|---|---|---|---|---|---|---|
| 1 | Failure | NA | 8 | 20.7 | 5.12 | 2.59 |
| 2 | Failure | NA | 8 | 24.7 | 4.36 | 3.09 |
| 3 | Failure | Cure | 8a | >30 | 6.73 | >3.75 |
| 4 | Unevaluable | NA | NA | >30 | 4.9 | NA |
| 5 | Cure | NA | 8 | 20.9 | 3.97 | 2.61 |
| 6 | Failure | NA | 8 | 16.3 | 3.89 | 2.04 |
| 7 | Cure | NA | 8 | 16.8 | 4.56 | 2.1 |
| 8 | Failure | NA | 4 | 28.2 | 6.84 | 7.05 |
| 9 | Failure | NA | 8 | Missing | 3.64b | NA |
| 10 | Unevaluable | Cure | 4c | 15 | 4.59 | 3.75c |
| 11 | Failure | NA | 4 | 15 | 3.75b | 3.75 |
| 12 | Unevaluable | NA | NA | 15.7 | 4.22b | NA |
| 13 | Failure | NA | 8 | Missing | 4.07 | NA |
Abbreviations: Cmax, peak serum concentration; ID, identifier; MIC, minimum inhibitory concentration; NA, not applicable.
aPharyngeal and rectal isolate with same gentamicin MIC.
bAdjusted body weight used to determined weight-based dosing for obese participants (body mass index >30 kg/m2).
cMIC and Cmax/MIC ratio are reported for rectal isolate.