TABLE 1. Cancers of oral cavity and pharynx with ICD-O-3 code by anatomic site and HPV association status,* — United States, 2007 and 2016.
| Anatomic site | ICD-O-3 code | HPV-associated | No. of cases (%) |
|
|---|---|---|---|---|
| 2007 | 2016 | |||
|
Oral cavity and pharynx (all sites)
|
C00-C14
|
No
|
35,076 (100)
|
44,419 (100)
|
| Lip |
C00.0-C00.9 |
No |
2,048 (6) |
1,847 (4) |
| Base of tongue |
C01.9, C02.4, C02.8 |
Yes |
5,661 (16) |
8,164 (18) |
| Anterior tongue |
C02.0-C02.3, C02.9 |
No |
4,422 (13) |
6,155 (14) |
| Floor of mouth |
C04.0-C04.9 |
No |
2,073 (6) |
1,978 (4) |
| Gum |
C03.0, C03.1, C03.9 |
No |
1,215 (3) |
1,727 (4) |
| Soft palate and uvula |
C05.1, C05.2 |
Yes |
870 (2) |
743 (2) |
| Hard palate |
C05.0, C05.8, C05.9 |
No |
767 (2) |
859 (2) |
| Cheek and other mouth |
C06.0-C06.9 |
No |
2,057 (6) |
2,463 (6) |
| Salivary gland |
C07.9-C08.9 |
No |
3,862 (11) |
4,433 (10) |
| Tonsil |
C09.0-C09.9 |
Yes |
5,791 (17) |
8,792 (20) |
| Oropharynx |
C10.0-C10.9 |
Yes |
1,507 (4) |
2,165 (5) |
| Nasopharynx |
C11.0-C11.9 |
No |
1,779 (5) |
1,788 (4) |
| Hypopharynx |
C12.9-C13.9 |
No |
2,307 (7) |
2,211 (5) |
| Other oral cavity and pharynx | C14.0-C14.8 | Yes | 717 (2) | 1,094 (2) |
Abbreviations: HPV = human papilloma virus; ICD-O-3 = International Classification of Diseases for Oncology, Third Edition.
* HPV-associated cancers are defined as cancers at specific anatomic sites with specific cell types in which HPV DNA frequently is found. These include ICD-O-3 site codes C01.9, C02.4, C02.8, C05.1, C05.2, C09.0, C09.8, C09.9, C10.0, C10.1, C10.2, C10.3, C10.4, C10.8, C10.9, C14.0, C14.2, and C14.8, with squamous cell carcinomas (histology codes: 8050–8084 and 8120–8131).