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. Author manuscript; available in PMC: 2021 Dec 22.
Published in final edited form as: J Am Coll Cardiol. 2020 Dec 22;76(25):2968–2976. doi: 10.1016/j.jacc.2020.10.035

Central illustration: Flowchart and Kaplan Meier curves showing the impact of deterioration in hepatorenal function on survival.

Central illustration:

Top: Flowchart showing patients that had low MELD-XI score at baseline and during follow-up (black), patients that moved from low to high MELD-XI score during follow-up (blue), and patients that had high MELD-XI score at baseline and during follow-up (red). Bottom: Compared to the patients that remained in the low MELD-XI class (black), those that developed high MELD-XI score during follow-up (blue) had lower 210-year transplant-free survival (97% vs 86%, p=0.006). Patients with high MELD-XI score at baseline and during follow-up had the lowest survival of the 3 groups (78%). p=0.01 represent curve comparison across all 3 groups using log-rank test.