Table 1.
Participant Characteristics and Outcomes by Early Fungicidal Activity (EFA) Group
| EFA Group, log10 CFU/mL/day | |||||
|---|---|---|---|---|---|
| ≥0.40 | 0.30–0.39 | 0.20–0.29 | ≤0.19 | P-value | |
| N | 352 | 112 | 87 | 187 | |
| Age, years | 35 [29, 41] | 36 [30, 41] | 35 [30, 38] | 35 [30, 40] | .73 |
| Men | 203 (58%) | 71 (63%) | 50 (58%) | 127 (68%) | .11 |
| Prior cryptococcosis | 30 (9%) | 6 (5%) | 12 (14%) | 22 (12%) | .13 |
| Receiving ART | 131 (37%) | 35 (31%) | 41 (47%) | 70 (37%) | .15 |
| TB diagnosis at baseline | 20 (5.7%) | 8 (7.1%) | 8 (9.2%) | 16 (8.6%) | .52 |
| Glasgow coma scale < 15 | 140 (40%) | 43 (38%) | 36 (41%) | 68 (37%) | .87 |
| Hemoglobin, g/dL | 11.7 [10.4, 13.1] | 11.6 [9.5, 13.5] | 11.8 [10.4, 13.2] | 11.8 [10.0, 13.5] | .82 |
| CD4 count, cells/μL | 20 [8, 56] | 16 [6, 51] | 14 [6, 46] | 11 [6, 35] | <.01 |
| CSF quantitative culture, CFU/mL | 87 000 [4 600, 425 000] | 112 000 [8 000, 430 000] | 43 000 [1 000, 290 000] | 54 000 [3 000, 250 000] | .03 |
| CSF pressure, >25 cmH 2 O | 191 (65%) | 49 (50%) | 42 (58%) | 99 (61%) | .08 |
| CSF ≥ 5 white cells/μL | 164 (47%) | 54 (51%) | 34 (40%) | 55 (30%) | <.001 |
| 18-week mortality | 129 (37%) | 44 (39%) | 31 (36%) | 93 (50%) | .02 |
Data are n (%) or median [P25, P75]. P-values from Kruskall-Wallis test for medians or χ 2 test for proportions.
Abbreviations: ART, antiretroviral therapy; CFU, colony-forming units; CSF, cerebrospinal fluid; EFA, early fungicidal activity; HIV, human immunodeficiency virus; TB, tuberculosis.