Table 2.
Baseline-Adjusted Means at 144 Weeks of Follow-up for Bone Resorption and Bone Mineral Density Outcomes by Treatment Arm
| Variable and Treatment | No. | Adjusted Mean (95% CI)a | Mean Difference (95% CI) | P |
|---|---|---|---|---|
| CTx, ng/mL | ||||
| ART + ZOL | 21 | 0.196 (.140, .251) | 0.049 (−.020, .119) | .1604 |
| ART + PL | 20 | 0.146 (.105, .187) | … | |
| Osteocalcin, ng/mL | ||||
| ART + ZOL | 21 | 12.966 (7.472, 18.459) | 4.160 (−1.851, 10.172) | .1741 |
| ART + PL | 20 | 8.805 (6.365, 11.246) | … | |
| Lumbar spine, g/cm2 | ||||
| ART + ZOL | 29 | 1.306 (1.258, 1.354) | −0.129 (−.199, −.057) | .0005 |
| ART + PL | 20 | 1.177 (1.125, 1.230) | … | |
| Lumbar spine, t score | ||||
| ART + ZOL | 29 | 0.780 (.368, 1.193) | −1.089 (−1.685, −.472) | .0005 |
| ART + PL | 20 | −0.298 (−.743, .146) | … | |
| Lumbar spine, z score | ||||
| ART + ZOL | 29 | 0.054 (−.338, .446) | −1.033 (−1.594, −.471) | .0004 |
| ART + PL | 20 | −0.979 (−1.380, −.577) | … | |
| Hip, g/cm2 | ||||
| ART + ZOL | 29 | 1.074 (1.035, 1.112) | −0.063 (−.128, .002) | .0556 |
| ART + PL | 20 | 1.010 (.958, 1.062) | … | |
| Hip, t score | ||||
| ART + ZOL | 29 | 0.018 (−.304, .341) | −0.487(−1.016, .041) | .0705 |
| ART + PL | 20 | −0.469 (−.888, −.050) | … | |
| Hip, z score | ||||
| ART + ZOL | 29 | −0.713 (−1.035, −.391) | −0.534 (−1.004, −.065) | .0259 |
| ART + PL | 20 | −1.247 (−1.589, −.906) | … | |
| Femoral neck, g/cm2 | ||||
| ART + ZOL | 29 | 1.058 (1.016, 1.100) | −0.046 (−.112, .020) | .1712 |
| ART + PL | 20 | 1.012 (.961, 1.064) | … | |
| Femoral neck, t score | ||||
| ART + ZOL | 29 | 0.064 (−.286, .414) | −0.357 (−.899, .185) | .1956 |
| ART + PL | 20 | −0.293 (−.707, .121) | … | |
| Femoral neck, z score | ||||
| ART + ZOL | 29 | −0.571 (−.868, −.274) | −0.362 (−.827, .1026) | .1261 |
| ART + PL | 20 | −0.934 (−1.291, −.576) | … |
Abbreviations: ART, antiretrovial therapy; CI, confidence interval; CTx, C-terminal telopeptide of collagen; PL, active placebo; ZOL, zoledronic acid.
aAdjusted mean defined as the predicted response value obtained by fitting the regression equation for each treatment arm at the mean baseline value for the 2 treatment arms and estimated using analysis of covariance at 144 weeks for each outcome.