Table 1.
Participant Characteristics
| CF | Overall n = 23 | Control | Overall n = 15 | P Values (CF vs Control) | ||||
|---|---|---|---|---|---|---|---|---|
| Hypo[+] n = 15 | Hypo[–] n = 8 | Hypo[+] n = 8 | Hypo[–] n = 7 | Overall | Hypo[+] | |||
| Female, n (%) | 7 (47) | 3 (37.5) | 10 (43) | 2 (25) | 3 (43) | 5 (33) | 0.54 | 0.33 |
| Age | 25.7 (14.6-30.6) | 23.6 (19.2-29.4) | 24.8 (14.6-30.6) | 25.5 (21-35) | 26 (23-38) | 26 (21-38) | 0.08 | 0.37 |
| Height (cm) | 164.7 (158.7-182.2) | 171.2 (161-187) | 165 (158.7-186.9) | 169.5 (155.5-181) | 170 (155.5-186.2) | 170 (155.5-186.2) | 0.69 | 0.63 |
| Weight (kg) | 61.9 (47.4-78.3) | 60.5 (46.4-79.4) | 61.9 (46.4-79.4) | 72.6 (55.6-87.2) | 69.4 (57.6-87.9) | 70.8 (55.6-87.9) | 0.02 | 0.09 |
| BMI-z | 0.15 (–1.9 to 1.2) | 0.12 (–2.4 to 0.51) | 0.12 (–2.44 to 1.23) | 0.44 (–0.43 to 1.2) | 0.66 (–0.3 to 1.2) | 0.61 (–0.43 to 1.22) | 0.03 | 0.15 |
| Fasting PG (mg/dL) | 88.8 (63.5-113.5) | 95.1 (79.3-106.8) | 91 (63.5-113.5) | 86.5 (75.9-107) | 91.2 (86.2-98.9) | 88.9 (75.9-107) | 0.57 | 0.69 |
| OGTT 1-hour PG (mg/dL) | 196.5 (113-272.5) | 210.9 (159-265) | 201.5 (113-272.5) | 139.8 (69.6-211.5) | 133.4 (109-193) | 136.8 (69.6-211.5) | <0.01 | 0.02 |
| OGTT 2-hour PG (mg/dL) | 121.1 (47.2-197) | 192.3 (112-266) | 145.9 (47.2-266) | 95.5 (60.4-145) | 105.1 (88.9-127.5) | 99.9 (60.4-145) | <0.01 | 0.11 |
| Normal glucose tolerance | 2 (13) | - | 2 (9) | 5 (62) | 6 (86) | 11 (73) | ||
| Early glucose intolerance | 7 (47) | 1 (13) | 8 (35) | 2 (25) | 1 (14) | 3 (20) | ||
| Impaired glucose tolerance | 6 (40) | 4 (50) | 10 (43) | 1 (13) | - | 1 (7) | ||
| Diabetes | - | 3 (37) | 3 (13) | - | - | - | ||
| FEV 1 % predicted | 89 (48-128) | 74 (32-96) | 86 (32-128) | |||||
| Genotype, n (%) delF508 heterozygous | 6 (40) | 2 (25) | 8 (35) | |||||
| Genotype, n (%) delF508 homozygous | 6 (40) | 5 (63) | 11 (48) | |||||
| Modulator therapy, n (%) | 9 (60) | 6 (75) | 15 (65) |
Data are expressed as median (minimum-maximum). Comparisons were performed between the CF and Control Overall and Hypo [+] subgroups. Italics represent P < 0.05 for CF-Hypo [+] versus CF-Hypo [–].
Abbreviations: BMI, body mass index; CF, cystic fibrosis; FEV1, forced expiratory volume in 1 second; Hypo, hypoglycemia; OGTT, oral glucose tolerance test; PG, plasma glucose.