Table 2.
OGTT Responses During the First 30 Minutes and the Last 60 Minutes of Observation Post-Ingestion
| CF | Control | P Values (CF vs Control) | ||||||
|---|---|---|---|---|---|---|---|---|
| Hypo[+] | Hypo[–] | Overall | Hypo[+] | Hypo[–] | Overall | Overall | Hypo+ | |
| Glucose AUC 0-30min | 3574.5 (2842.5-4719.5) | 3641.5 (2998.5- 3903.4) | 3606.5 (2842.5- 4719.5) | 3258.1 (2484.2- 4102.5) | 3419.3 (3304.4- 3769.4) | 3387.8 (2484.2- 4102.5) | 0.2 | 0.25 |
| Insulin AUC 0-30min (μU ∙min/mL) | 372.5 (175.75-774.5) | 308.5 (91.5- 583.75) | 372.5 (91.5-774.5) | 891.4 (619.3-2270) | 904.8 (424.8-1242.3) | 904.8 (424.8-2270) | <0.01 | <0.01 |
| C-peptide AUC 0-30min (ng∙min/dL) | 71.9 (43.2-93.1) | 57.2 (32.8- 75.2) | 67.6 (32.8-93.1) | 107.6 (48.3-130.5) | 97.8 (55.1-114.4) | 99.7 (48.3-130.5) | <0.01 | 0.01 |
| ISR AUC 0-30min (μU/mL) | 2056 (1227-3789.5) | 1559.6 (788- 2685.2) | 1786.1 (788-3789.5) | 4046.6 (2504.3- 5220.2) | 3863.8 (738.3-4231.2) | 3990.7 (738.3- 5220.2) | <0.01 | <0.01 |
| Glucose AUC 120-180min | –320.6 (–1253.3 to 4101.8) | 2580.8 (108- 9079.5) | 1088.3 (–1253.3 to 9079.5) | –797 (1386.3 to 523.5) | 145 (–565.3 to 2136.2) | –565.3 (–1386.3 to 2136.2) | 0.02 | 0.04 |
| Insulin AUC 120-180min (μu ∙min/mL) | 1015.5 (510-3395.3) | 1497.8 (354.8- 2670.8) | 1046.3 (354.8- 3395.3) | 450.8 (10.5-2160) | 894 (246-1197) | 703.5 (10.5-2160) | <0.01 | <0.01 |
| C-peptide AUC 129-180min (ng∙min/dL) | 260.3 (174.5-634.2) | 297 (139.6- 599.7) | 285.9 (139.6-634.2) | 114.3 (24-300.6) | 189 (62-318.6) | 135 (24-318.6) | <0.01 | <0.01 |
| ΔGlucagon 120-180min (pg/mL) | –5 (–214 to 21) | –4.5 (–26 to 7) | –5 (–214 to 21) | 10.5 (–1 to 39) | –11 (–22 to 19) | 3 (–22 to 9) | <0.01 | <0.01 |
| ΔFFA 120-180min (mM) | 0.007 (–0.06 to 0.35) | –0.009 (–0.036 to 0.033) | –0.003 (–0.062 to 0.353) | 0.34 (–0.008 to 0.42) | 0.025 (–0.018 to 0.83) | 0.064 (–0.018 to 0.829) | <0.01 | 0.01 |
Data are expressed as median (minimum-maximum). Comparisons in this table include rank-sum testing performed between the CF and Control Overall and Hypo [+] subgroups. Italics represent P < 0.05 for CF-Hypo [+] vs CF-Hypo [–].
Abbreviations: AUC, area under the curve; CF, cystic fibrosis; FFA, free fatty acid; Hypo, hypoglycemia; ISR, insulin secretory rate.