Table 3.

Comparison of endogenous exposure and dosed exposure (hypothetical) to doubly cysteinylated IgG2-A. Included are the mean values for parameters relevant to the exposure calculations

	Endogenous		Dosed therapeutic (hypothetical)
Parameter	Mean value	Ref	Mean value	Ref
IgG serum concentration	11.8 mg/mL	ref.31	0.1 mg/mL*	n/a
%IgG2	22%	ref.25	100%	n/a
%IgG2-A (of IgG2)	7.2%	ref.19	25%	n/a
%2Cys (of IgG2-A)	0.8%	This study	0.5%	n/a
Doubly cysteinylated IgG2-A exposure in serum	1.5 µg/mL		0.125 µg/mL

*Assuming a hypothetical IgG2 therapeutic dose of 250 mg and an average human serum volume of 2.5L.