Table 1. Baseline demographics, clinical and laboratory features of serious non-AIDS-defining events among cART-naive HIV/AIDS patients.
| Variables | Serious NADE-free |
Serious NADEs | p | Serious NADEs | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Age | p | CD4 cell | p | ||||||||
| <50 Years | 50-65 Years | ≥65 Years | >350 cells/ul | 200-350cells/ul | ≤200 cells/ul | ||||||
| Patients number (%) | 1166(100) | 143(100) | - | 83(100) | 43(100) | 17(100) | - | 12(100) | 18(100) | 113(100) | - |
| Age (yrs) § | 36(28-45) | 46(37-58) | <0.001 | 39(32-44) | 57(51-61) | 69(67-73) | <0.001 | 47.5(41.5-65.5) | 46(41.5-53) | 45(35.5-58) | 0.490 |
| Age<50 years | 995(85.3) | 83(58.0) | <0.001 | 83(100) | - | - | - | 7(58.3) | 10(55.6) | 66(58.4) | 0.642* |
| 50≤Age<65 years | 156(13.4) | 43(30.1) | - | 43(100) | - | 2(16.7) | 7(38.9) | 34(30.1) | |||
| Age≥65 years | 15(1.3) | 17(11.9) | - | - | 17(100) | 3(25.0) | 1(5.6) | 13(11.5) | |||
| Sex-Male (%) | 1061(91.0) | 127(88.8) | 0.395 | 74(89.2) | 36(83.7) | 17(100) | 0.080▲ | 9(75.0) | 16(88.9) | 102(90.3) | 0.154* |
| Cigarette smoking history (%) | 308(26.4) | 55(38.5) | 0.002 | 34(41.0) | 17(39.5) | 4(23.5) | 0.257* | 8(66.7) | 6(33.3) | 41(36.3) | 0.102* |
| Alcohol drinking history (%) | 257(22.0) | 37(25.9) | 0.300 | 21(25.3) | 14(32.6) | 2(11.8) | 0.600* | 5(41.7) | 8(44.4) | 24(21.2) | 0.048 |
| Transmission route | |||||||||||
| Homosexual (%) | 862(73.9) | 107(74.8) | 0.589* | 61(73.4) | 30(69.8) | 16(94.1) | 0.067▲ | 8(66.7) | 14(77.8) | 85(75.2) | 0.231▲ |
| Heterosexual (%) | 198(17.0) | 19(13.3) | 10(12.0) | 9(20.9) | 0(0.0) | 3(25.0) | 4(22.2) | 12(10.6) | |||
| Blood transfusion (%) | 90(7.7) | 13(9.1) | 8(9.6) | 4(9.3) | 1(5.9) | 1(8.3) | 0(0.0) | 12(10.6) | |||
| Intravenous drug (%) | 16(1.4) | 4(2.8) | 4(4.8) | 0(0.0) | 0(0.0) | 0(0.0) | 0(0.0) | 4(3.5) | |||
| Laboratory Results | . | ||||||||||
| CD4 (cells/ul) § | 40(13-189) | 69(14-180) | 0.957 | 72(15-183) | 70(12-175) | 65(29.5-230.5) | 0.843 | 558(494.25-708) | 281(246.5-301) | 45(10.5-118.5) | <0.001 |
| TC (mmol/L)§ | 3.25(2.73-3.94) | 3.35(2.75-4.04) | 0.482 | 3.28(2.42-3.91) | 3.58(2.82-4.08) | 3.21(2.74-4.21) | 0.476 | 4.185(3.44-4.8025) | 4.065(2.5375-4.425) | 3.24(2.675-3.85) | 0.005 |
| TG (mmol/L)§ | 1.18(0.87-1.7325) | 1.36(0.91-1.98) | 0.053 | 1.30(0.84-1.95) | 1.37(0.96-2.06) | 1.36(0.80-1.94) | 0.877 | 1.23(0.79-2.11) | 1.64(0.86-2.07) | 1.29(0.925-1.94) | 0.395 |
| HDL (mmol/L)§ | 0.66(0.51-0.8525) | 0.68(0.52-0.81) | 0.213 | 0.67(0.47-0.81) | 0.74(0.60-0.84) | 0.58(0.46-0.805) | 0.287 | 0.765(0.72-0.975) | 0.69(0.6-0.845) | 0.65(0.475-0.805) | 0.030 |
| LDL (mmol/L)§ | 2.03(1.59-2.582) | 2.1(1.59-2.51) | 0.447 | 2.17(1.50-2.58) | 2.05(1.59-2.51) | 1.87(1.58-2.45) | 0.872 | 2.645(1.785-3.0825) | 2.16(1.3725-2.5725) | 2.07(1.535-2.48) | 0.136 |
| CD4>350 cells/ul (%) | 178(15.3) | 12(8.4) | 0.044 | 7(8.4) | 2(4.7) | 3(17.6) | 0.642* | 12(100) | - | - | - |
| 200<CD4≤350cells/ul (%) | 103(8.8) | 18(12.6) | 10(12.0) | 7(16.3) | 1(5.9) | - | 18(100) | - | |||
| CD4≤200 cells/ul (%) | 885(75.9) | 113(79.0) | 66(79.5) | 34(79.1) | 13(76.5) | - | - | 113(100) | |||
| CD4/CD8<1 (%) | 1145(98.2) | 140(97.9) | 1.000* | 80(96.4) | 43(100) | 17(100) | 0.191▲ | 9(75.0) | 18(100) | 113(100) | <0.001▲ |
| TC≥6.2mmol/L (%) | 12(1.0) | 4(2.8) | 0.158* | 3(3.6) | 0(0.0) | 1(5.9) | 0.214▲ | 0(0.0) | 2(11.1) | 2(1.8) | 0.147▲ |
| TG≥2.3mmol/L (%) | 143(12.3) | 25(17.5) | 0.078 | 15(18.1) | 7(16.3) | 3(17.6) | 0.885* | 3(25.0) | 3(16.7) | 19(16.8) | 0.553* |
| HDL≤1mmol/L (%) | 1017(87.2) | 133(93.0) | 0.046 | 78(94.0) | 38(88.4) | 17(100) | 0.150▲ | 10(83.3) | 16(88.9) | 107(94.7) | 0.102* |
| LDL≥3.12mmol/L (%) | 104(8.9) | 13(9.1) | 0.946 | 6(7.2) | 5(11.6) | 2(11.8) | 0.406* | 3(25.0) | 2(11.1) | 8(7.1) | 0.048* |
| AIDS-Defining Events | |||||||||||
| CMV Infection (%) | 112(9.6) | 10(7.0) | 0.310 | 6(7.2) | 3(7.0) | 1(5.9) | 0.857* | 0(0.0) | 0(0.0) | 10(8.8) | 0.086▲ |
| TB (%) | 305(26.1) | 33(23.1) | 0.427 | 15(18.1) | 13(30.2) | 5(29.4) | 0.247 | 0(0.0) | 3(16.7) | 30(26.5) | 0.024▲ |
| PCP (%) | 76(6.5) | 6(4.2) | 0.279 | 4(4.8) | 2(4.7) | 0(0.0) | 0.459▲ | 0(0.0) | 0(0.0) | 6(5.3) | 0.235▲ |
| Cryptococcosis (%) | 68(5.8) | 6(4.2) | 0.424 | 4(4.8) | 2(4.7) | 0(0.0) | 0.459▲ | 0(0.0) | 0(0.0) | 6(5.3) | 0.235▲ |
| Invasive fungal infection (%) | 418(35.8) | 40(28.0) | 0.062 | 22(26.5) | 12(27.9) | 6(35.3) | 0.763 | 0(0.0) | 2(11.1) | 38(33.6) | 0.002▲ |
| ADCs (%) | 27(2.3) | 7(4.9) | 0.057 | 5(6.0) | 2(4.7) | 0(0.0) | 0.382▲ | 0(0.0) | 1(5.6) | 6(5.3) | 0.532▲ |
| Severe pneumonia (%) | 228(19.5) | 37(25.9) | 0.076 | 22(26.5) | 8(18.6) | 7(41.2) | 0.194 | 0(0.0) | 0(0.0) | 37(32.7) | <0.001▲ |
| Complications | |||||||||||
| Diabetes (%) | 26(2.2) | 11(7.7) | <0.001 | 4(4.8) | 4(9.3) | 3(17.6) | 0.069 | 1(8.3) | 1(5.6) | 9(8.0) | 0.906* |
| Hypertension (%) | 208(17.8) | 60(42.0) | <0.001 | 24(28.9) | 25(58.1) | 11(64.7) | 0.001 | 5(41.7) | 9(50.0) | 46(40.7) | 0.759 |
| Syphilis (%) | 265(22.7) | 33(23.1) | 0.925 | 19(22.9) | 11(25.6) | 3(17.6) | 0.827* | 3(2.1) | 2(11.1) | 28(24.8) | 0.585* |
| Chronic hepatitis B (%) | 90(7.7) | 16(11.2) | 0.151 | 11(13.3) | 4(9.3) | 1(5.9) | 0.321* | 0(0.0) | 1(5.6) | 15(13.3) | 0.135▲ |
| Chronic hepatitis C (%) | 46(4.0) | 12(8.4) | 0.015 | 10(12.0) | 2(4.7) | 0(0.0) | 0.075▲ | 1(0.7) | 2(11.1) | 9(8.0) | 0.816* |
| Serious NADEs | |||||||||||
| NADCs (%) | - | 37(25.9) | - | 24(28.9) | 10(23.3) | 3(17.6) | 0.284 | 6(4.2) | 7(38.9) | 24(21.2) | 0.039 |
| CVD (%) | - | 26(18.2) | - | 10(12.0) | 9(20.9) | 7(41.2) | 0.015 | 3(2.1) | 2(11.1) | 21(18.6) | 0.898* |
| Cerebrovascular Diseases (%) | - | 49(34.3) | - | 26(31.3) | 17(39.5) | 6(35.3) | 0.652 | 2(1.4) | 4(22.2) | 43(38.1) | 0.067* |
| Liver cirrhosis (%) | - | 18(12.6) | - | 12(14.5) | 5(11.6) | 1(5.9) | 0.332* | 1(0.7) | 2(11.1) | 15(13.3) | <0.001* |
| CKD (%) | - | 28(19.6) | - | 17(20.5) | 7(16.3) | 4(23.5) | 0.982* | 0(0.0) | 4(22.2) | 24(21.2) | <0.001▲ |
| Death (%) | 74(6.3) | 17(11.9) | 0.014 | 11(13.3) | 2(4.7) | 4(23.5) | 0.755* | 0(0.0) | 5(27.8) | 12(10.6) | 0.014▲ |
Note
*Continuous correction method
▲ Likelihood test
§ mean evaluation based on 25th, 75th percentile; ADC: AIDS-defining cancer; ADE: AIDS-defining event; CKD: chronic kidney disease; CVD: cardiovascular disease; HDL: high density lipoprotein; LDL: low density lipoprotein; NADE: non-AIDS-defining event; TC: total cholesterol; TG: triglyceride; CMV:cytomegalovirus; TB:tuberculosis; PCP: Pneumocystis pneumonia; NADC: non-AIDS-defining cancer.