Table 1:
Baseline demographics at time of listing for patients listed for heart transplant with restrictive, infiltrative and hypertrophic cardiomyopathies, pre- vs post-policy change
| Era 1 | Era 2 | p-value | |
|---|---|---|---|
| n | 855 | 377 | |
| Male (%) | 531 (62.1) | 245 (64.9) | 0.33 |
| Age | 56 (45-63) | 55 (45-63) | 0.39 |
| Ethnicity (%) | 0.15 | ||
| White | 614 (71.8) | 247 (65.5) | |
| Black | 163 (19.1) | 85 (22.5) | |
| Hispanic | 47 (5.5) | 28 (7.4) | |
| Other | 31 (3.6) | 17 (4.5) | |
| BMI | 26.7 (23.6-30.4) | 27.4 (23.6-31.8) | 0.11 |
| HF Etiology (%) | 0.05 | ||
| Amyloidosis | 211 (24.7) | 97 (25.7) | |
| HCM | 367 (42.9) | 161 (42.7) | |
| Sarcoidosis | 119 (13.9) | 69 (18.3) | |
| RCM | 158 (18.5) | 50 (13.3) | |
| Blood Type | 0.12 | ||
| A | 315 (36.8) | 138 (39.3) | |
| B | 133 (15.6) | 39 (10.3) | |
| AB | 38 (4.4) | 17 (4.5) | |
| O | 369 (43.2) | 173 (45.9) | |
| UNOS Status at Listing | <0.001 | ||
| Status 1A/Status 1 | 174 (20.4) | 11 (2.9) | |
| Status 2 | 53 (14.1) | ||
| Status 3 | 32 (8.5) | ||
| Status 1B/Status 4 | 296 (34.6) | 216 (57.3) | |
| Status 2/Status 5 | 375 (43.9) | 5 (1.3) | |
| Status 6 | 55 (14.6) | ||
| Temporarily Inactive | 10 (1.1) | 5 (1.3) | |
| ICD (%) | 577 (67.5) | 258 (68.4) | 0.84 |
| Amyloidosis | 87 (12.3) | 41 (15.9) | |
| HCM | 375 (53.1) | 133 (51.6) | |
| Sarcoidosis | 139 (19.7) | 60 (23.3) | |
| RCM | 105 (14.9) | 24 (9.3) | |
| Diabetes Mellitus (%) | 138 (16.2) | 69 (18.3) | 0.35 |
| Symptomatic Cerebrovascular Disease (%) | 59 (6.9) | 18 (4.8) | 0.33 |
| CKD (%) | 0.62 | ||
| GFR>60 | 496 (58.3) | 229 (61.2) | |
| GFR 30-60 | 229 (38.7) | 134 (35.8) | |
| GFR<30 | 26 (3.1) | 11 (2.9) | |
| MELD-Xi | 9.5 (5.9-13.5) | 9.6 (5.9-12.4) | 0.55 |
| Hemodynamics | |||
| PA Systolic | 42 (33-51) | 40 (30-50) | 0.04 |
| PA Diastolic | 21 (15-26) | 20 (14-25) | 0.02 |
| PA Mean | 29 (22-36) | 27 (20-35) | 0.01 |
| PCWP | 20 (15-25) | 18 (12-24) | 0.001 |
| Cardiac Index | 1.93 (1.62-2.30) | 1.95 (1.68-2.30) | 0.35 |
Legend: BMI, body mass index; CKD, chronic kidney disease; GFR, glomerular filtration rate; HCM, hypertrophic cardiomyopathy; HF, heart failure; ICD, implantable cardioverter defibrillator; MELD-Xi, model for end-stage liver disease excluding INR; PA, pulmonary artery; PCWP, pulmonary capillary wedge pressure; RCM, restrictive cardiomyopathy.
Data are presented as n (%) or median (IQR)