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. 2020 Dec 10;16(12):e1009244. doi: 10.1371/journal.pgen.1009244

Fig 6. MCH signaling counteracts melanocortin system activity to promote melanosome contraction in adult zebrafish.

Fig 6

(A-D) Loss of function phenotype on skin pigmentation from white adapted adult control (A), pomca (B), mchr2 (C) or double mchr2; pomca (D) homozygous mutant. (E-G) Loss of function phenotype on skin pigmentation from black adapted adult control (E), pomca (F), mchr2 (G) or double mchr2; pomca (H) homozygous mutant. Similar to the pomca homozygous mutant, pomca; mchr2 double homozygous mutant phenotype is characterized by melanosome contraction on a black background, indicating that pomca loss of function is sufficient to allow melanosome contraction in absence of MCH signaling in adult zebrafish. Lateral view (E-G).