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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Genes Chromosomes Cancer. 2020 Oct 7;60(1):43–48. doi: 10.1002/gcc.22895

FIGURE 1.

FIGURE 1

Two discrete chordoma morphologies were observed. A, The poorly differentiated component was composed of a high cellularity proliferation of atypical, mitotically-active epithelioid to rhabdoid cells tightly arranged in vague nests and cords without cytoplasmic vacuolization or an extracellular matrix. B, The conventional component was composed of a lower cellularity proliferation of monomorphic epithelioid cells with large, clear cytoplasmic vacuoles and small nuclei arranged in cords and clusters within a myxoid matrix. Diffuse immunoreactivity for brachyury was present in both the poorly differentiated (C) and conventional (D) components, and nuclear immunoreactivity for INI1 was absent in both the poorly differentiated (E) and conventional (F) components.