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. Author manuscript; available in PMC: 2020 Dec 22.
Published in final edited form as: Mol Pharm. 2015 Oct 2;12(11):3986–3998. doi: 10.1021/acs.molpharmaceut.5b00432

Figure 4.

Figure 4.

Native LC/MS analysis comparing DAR compositions of conventional ADCs, 3 and 4, with cross-linked DBM ADCs, 5 and 6. The data shown are the deconvoluted MS profiles, and observed MWs are consistent with calculated MWs within ±2 AMUs. Average DAR values shown for each ADC were calculated based on peak intensities.