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(A) Tumor growth inhibition in Her2 positive SKOV3 xenograft mice treated twice (days 62 and 69) at 3 mg/kg. (B) Tumor growth inhibition in CD98 positive H446 (lung carcinoma) xenograft mice treated twice (days 41 and 48) at 3 mg/kg. (C) SKOV3 xenograft tumor model in NOG mice (insensitive to treatment with trastuzumab) treated once at 3 mg/kg with homogeneous (DBM) ADC 5 or with conventional (MC) ADC 3.
