Table 1.

Affinity of ADCs 3–6 for Their Purified Antigens, ErbB2 and CD98, Determined via SPR

antibody or ADC	antigen	ka (M−1 s−1)	kd (s−1)	KD (nM)
trastuzumab	ErbB2	6.1 × 105	1.4 × 10−4	0.23
5 (TRA–DBM-MMAF)	ErbB2	5.9 × 105	1.4 × 10−4	0.24
3 (TRA–MC-MMAF)	ErbB2	5.7 × 105	1.4 × 10−4	0.25
IGNX	CD98	1.6 × 105	2.1 × 10−4	0.14
6 (IGNX–DBM-MMAF)	CD98	1.4 × 105	2.6 × 10−4	0.18
4 (IGNX–MC-MMAF)	CD98	1.5 × 105	2.4 × 10−4	0.16