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. 2020 Dec 18;15:10331–10347. doi: 10.2147/IJN.S281029

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© 2020 Yang et al.

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(A) Heating curves for H₂O, PRMI-1640 medium, SPIO@APTES, SPIO@PSS/CDDP/HSA, and SPIO@PSS/CDDP/HSA–MTX nanoparticles. The concentration of SPIO@APTES was 0.622 mg/mL. (B) Number-based particle size distribution of SPIO@PSS/CDDP/HSA and SPIO@PSS/CDDP/HSA−MTX nanoparticles with or without RF exposure. (C) TEM images showing that RF irradiation affected the morphology of SPIO@PSS/CDDP/HSA and SPIO@PSS/CDDP/HSA−MTX nanoparticles. Scale bar=200 nm.