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. 2020 Dec 22;9:e56883. doi: 10.7554/eLife.56883

Figure 3. Kdm5a knockout mice have impaired dendritic morphogenesis.

Figure 3.

(A) Sholl analysis from Golgi-Cox-stained neurons revealed a reduction in dendritic complexity of cortical neurons from KO mice (red) compared to WT (black) littermates (***p<0.0001). Data were analyzed using two-way ANOVA followed by Tukey's multiple comparisons test. (Right) Representative tracings of Golgi-Cox-stained cortical layer II/III neurons. Golgi-Cox staining showed significantly reduced dendritic complexity (B, **p=0.0066), length (C, ***p<0.0001), and spine density (D, ***p<0.0001) of cortical neurons from KO mice compared to WT littermates. Data were obtained from basal dendrites of cortical layer II/III neurons from mice at 14–16 weeks of age. Data were analyzed using unpaired t test. All values are mean ± SEM (n = 15 WT, 15 KO).