Author response image 2. A reconstruction of a hantaviral spike using particles manually picked from “break points” in the lattice.

The resulting map displays an empty patch of membrane where an 8^th neighbour would normally be expected as indicated with a dashed circle. Additional density that likely corresponds to fab P-4G2 is indicated with an asterisk. This reconstruction is generated from 160 manually picked and aligned particles and displayed at a resolution of 50 Å for clarity.