Fig. 2.

Maps of significant polarization in regulation and somatic copy number alteration (SCNA) along chromosome 17 across cancer types. (a) 17p is dominated by negative (-, blue) polarity in regulation, but 17q is more dominated by positive polarity (+, red) in regulation. Six loci surrounded by boxes are conserved in zone regulation polarity across cancer types. (b) Numbers of cancer types either positively (red) or negatively (blue) polarized in regulation along chromosomal loci. Loci are defined by intersections among zones. Dark red/blue bars indicate 14 (80%) or more of cancer types being identically polarized at a locus. Known cancer genes are marked along chromosomes. (c) Statistically significant zone polarization in SCNA along the chromosome across cancer types, corresponding to amplification (+, purple) and deletion (-, green), respectively. (d) Numbers of cancer types either positively (purple) or negatively (green) polarized in SCNA at loci along the chromosome. Dark purple/green bars indicate over 80% of cancer types are positively/negatively polarized in SCNA at a locus