Table 1.
Statistics of regulation zones and their polarization in 17 human cancer types
| Cancer study (project ID) | Sample size | #Zones | Outstanding | Positive+ | Negative- |
|---|---|---|---|---|---|
| Bladder Urothelial Carcinoma (BLCA) | 19×2 | 3752 | 1229 | 544 | 685 |
| Breast Invasive Carcinoma (BRCA) | 112×2 | 3615 | 2344 | 1126 | 1218 |
| Cholangiocarcinoma (CHOL) | 9×2 | 3984 | 1203 | 600 | 603 |
| Colon Adenocarcinoma (COAD) | 40×2 | 3733 | 1929 | 968 | 961 |
| Esophageal Carcinoma (ESCA) | 8×2 | 3708 | 443 | 206 | 237 |
| Head and Neck Squamous Cell Carcinoma (HNSC) | 43×2 | 3618 | 1666 | 852 | 814 |
| Kidney Chromophobe (KICH) | 23×2 | 3804 | 1994 | 947 | 1047 |
| Kidney Renal Clear Cell Carcinoma (KIRC) | 72×2 | 3699 | 2293 | 1098 | 1195 |
| Kidney Renal Papillary Cell Carcinoma (KIRP) | 31×2 | 3744 | 1763 | 801 | 962 |
| Liver Hepatocellular Carcinoma (LIHC) | 50×2 | 3656 | 1803 | 854 | 949 |
| Lung Adenocarcinoma (LUAD) | 57×2 | 3683 | 2076 | 1017 | 1059 |
| Lung Squamous Cell Carcinoma (LUSC) | 49×2 | 3730 | 2181 | 1064 | 1117 |
| Prostate Adenocarcinoma (PRAD) | 52×2 | 3663 | 1915 | 866 | 1049 |
| Rectum Adenocarcinoma (READ) | 9×2 | 3905 | 901 | 422 | 479 |
| Stomach Adenocarcinoma (STAD) | 27×2 | 3660 | 1228 | 585 | 643 |
| Thyroid Carcinoma (THCA) | 58×2 | 3681 | 2034 | 968 | 1066 |
| Uterine Corpus Endometrial Carcinoma (UCEC) | 23×2 | 3731 | 1490 | 709 | 781 |
Note: Numbers of significantly positively (+) and negatively (-) regulated zones are based on P-values (0.05) corrected for multiple testing by the Benjamini–Hochberg method.