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. Author manuscript; available in PMC: 2020 Dec 22.
Published in final edited form as: Neuroimage. 2020 May 4;217:116887. doi: 10.1016/j.neuroimage.2020.116887

Table 3.

Task-positive and task-negative brain regions showing up and down regulation, respectively, in response to the Load manipulation, in younger adults.

Brain Regions BA MNI Coordinates F Values Cluster size
x y z
Task-positive Regions (WM)
 Dorsolateral Prefrontal Cortex
  R Middle Frontal Gyrus 9 36 39 33 9.78 49
 Lateral Frontal Cortex
  L Inferior Frontal Gyrus 9 −48 9 24 9.63 155
  L Precentral Gyrus 6 −57 0 21 6.24
 Medial Frontal Cortex
  L Medial Frontal Gyrus 6 −9 15 48 8.43 115
  L Cingulate Gyrus 32 −6 21 42 8.14
  R Superior Frontal Gyrus 6 6 12 54 5.68
  R Cingulate Gyrus 32 6 27 33 5.93
 Parietal Cortex
  L Precuneus 7 −24 −63 42 10.65 333
  R Precuneus 7 9 −69 51 7.34 160
 Insula
  R Insula 13 33 18 3 7.97 72
Task-negative Regions (DMN)
 Medial Prefrontal Cortex
  L Superior Frontal Gyrus 9 −15 51 33 5.93 36†
 Temporo-Parietal Junction
  R Middle Temporal Gyrus 39 54 −69 30 7.55 121
  L Middle Temporal Gyrus 39 −45 −66 27 5.5 43†
 Posterior Cingulate Cortex/Precuneus
  L Precuneus 31 −9 −48 33 5.94 57†
  R Cingulate Gyrus 31 6 −48 30 5.96

Significance threshold is pFWE < 0.05 (see Materials and Methods). Cluster size is in voxels and reflects size after masking (logical “AND” conjunction) the F-maps with binarized composite random-effects t-maps identifying regions showing up and down regulation, respectively, in response to the Load manipulation (see Materials and Methods).

†

Significant at p < 0.001 and k = 30 voxels, uncorrected. Anatomical regions were identified using the Talairach Client (http://talairach.org) after transforming the SPM12 Montreal Neurological Institute coordinates to Talairach space using GingerALE (http://brainmap.org). WM, Working Memory; DMN, Default-Mode Network; L, Left; R, Right; BA, Brodmann Area.