Table 2.
Human (hsEH) and murine (msEH) sEH IC50 of the aromatic and heteroaromatic series of 2-oxaadamant-1-yl ureas.
 | |||
|---|---|---|---|
| Compound | R | IC50 (nM)[a] | |
| hsEH | msEH | ||
| 7 |  |
21.3 | 553 |
| 27 |  |
782 | 14721 |
| 28 |  |
911 | 3853 |
| 29 |  |
1448 | >100.000 |
| 30 |  |
52.6 | 1857 |
| 31 |  |
19.7 | 344 |
| 32 |  |
35.9 | 723 |
a
Reported IC50 values are the average of three replicates. The fluorescent assay as performed here has a standard error between 10 and 20% suggesting that differences of two-fold or greater are significant. Because of the limitations of the assay it is difficult to distinguish among potencies < 0.5 nM.25