. Author manuscript; available in PMC: 2021 Sep 10.

Published in final edited form as: J Med Chem. 2020 Aug 25;63(17):9237–9257. doi: 10.1021/acs.jmedchem.0c00310

Table 5:

Pharmacokinetic parameters in mouse for ip and iv administration routes of compound 22 at 1 mg/kg.

Route	T_1/2	T_max	C_max	C₀	AUC_last	AUC_{INF_obs}	V_z	Cl
Route	(h)	(h)	(ng/mL)	(ng/mL)	(h·ng/mL)	(h·ng/mL)	(L/kg)	(L/h/kg)
IP	3.02	0.16	117.33	-	34.67	35.20	124.02	28.41
IV	2.80	0.16	108.33	236.23	59.1	59.63	67.73	16.77