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. Author manuscript; available in PMC: 2020 Dec 22.
Published in final edited form as: ACS Chem Biol. 2018 Jan 10;13(3):533–536. doi: 10.1021/acschembio.7b01012

Figure 2.

Figure 2.

Comparison of silencing activity of the amide-modified siRNAs monitored separately for two different target RNAs, one complementary to the guide strand (darker colored bars) and one complementary to the passenger strand (lighter colored bars). (A) blue siRNA guide strands (GN) duplexed with the unmodified passenger strand (P0) or the ON-TARGETplus (OTP) modifications; (B) black siRNA guide strands (GN*) duplexed with the unmodified passenger strand (P0*) and the unmodified guide strand (G0*) duplexed with the amide-modified passenger strand (P1*); (C) green siRNA guide strands (GN#) duplexed with the unmodified passenger strand (P0#) and the unmodified guide strand (G0#) duplexed with the modified passenger strand (P1#); and (D) black siRNA guide strands (GN*) duplexed with the amide-modified passenger strand (P1*).