Table 1. Characteristics of patients referred with a suspected bleeding disorder ( n = 555; 2012–2017; described in Adler et al 16 ) .
| Characteristics | No bleeding disorder | Possible platelet function disorder a | Confirmed platelet function disorder a | Other bleeding disorders | Missing data |
|---|---|---|---|---|---|
| Numbers (%) or median (IQR) as appropriate | |||||
| Patients | 267 (48.0) | 64 (11.5) | 54 (9.7) | 170 (30.6) | 0 |
| Age (years) | 40.2 (27.3, 60.4) | 49.3 (34.9, 63.9) | 49.8 (33.5, 64.0) | 44.3 (30.7, 61.7) | 0 |
| Sex | |||||
| Female | 186 (69.7) | 52 (74.3) | 32 (66.7) | 101 (59.4) | 0 |
| Male | 81 (30.3) | 18 (25.7) | 16 (33.3) | 69 (40.6) | 0 |
| Reason for referral | 17 | ||||
| Bleeding tendency | 191 (75.5) | 63 (98.4) | 51 (94.4) | 148 (88.6) | |
| Abnormal coagulation tests | 25 (9.9) | 1 (1.6) | 0 (0) | 9 (5.4) | |
| Family history | 33 (13.0) | 0 (0) | 3 (5.6) | 6 (3.6) | |
| Re-evaluation | 4 (1.6) | 0 (0) | 0 (0) | 4 (2.4) | |
| Referring physician | 27 | ||||
| Primary care physician | 90 (35.9) | 22 (32.8) | 20 (42.6) | 68 (41.7) | |
| Gynecologist | 51 (20.3) | 18 (26.9) | 18 (38.3) | 34 (20.9) | |
| Other specialist | 110 (43.8) | 27 (40.3) | 9 (19.2) | 61 (37.4) | |
| ISTH-BAT score | 2 (1,3) | 4 (2, 7) | 7 (5, 9) | 4 (2, 7) | 15 |
| Antiaggregant treatment | 23 (9.5) | 11 (17.2) | 3 (6.8) | 17 (10.8) | 47 |
| Anticoagulant treatment | 13 (4.9) | 3 (4.7) | 2 (3.7) | 16 (9.5) | 3 |
| SSRI treatment | 16 (6.7) | 8 (14.3) | 4 (8.3) | 7 (4.1) | 57 |
| VWF antigen | 110 (82, 136) | 101 (79, 136) | 98 (79, 133) | 93 (57, 134) | 72 |
| VWF activity | 107 (81, 131) | 99 (72, 126) | 100 (75, 137) | 84 (55, 126) | 73 |
| Platelet count | 235 (200, 267) | 256 (223, 307) | 235 (186, 270) | 227 (184, 273) | 4 |
Abbreviations: IQR, interquartile range; SSRI, selective serotonin uptake inhibitors; VWF, von Willebrand factor; ISTH-BAT, bleeding assessment tool of the International Society on Thrombosis and Hemostasis.
a
Diagnosis of a platelet function disorder was made using light transmission aggregometry and platelet flow cytometry. “Confirmed platelet function disorder” was defined as abnormal results in repeated latent transition analysis/flow cytometry measurements in the absence of other disorders, “possible platelet function disorder” as an abnormal result in one measurement available, inconclusive results, or presence of concomitant disorder.