Table 2.
Univariable and Multivariable Logistic Regression Analyses Assessing the Association Between Increased Inflammatory Blood Cell Counts and Health-Related Quality of Life Independent of hs-CRP Levels.
| Univariable | Multivariable (Model 1) | Multivariable (Model 2) | ||||
|---|---|---|---|---|---|---|
| Odds Ratio (95% CI) | P Value | Odds Ratio (95% CI) | P Value | Odds Ratio (95% CI) | P Value | |
| Leukocytosis | ||||||
| Physical functioning | 1.91 (1.79-2.03) | <0.001 | 1.24 (1.16-1.34) | <0.001 | 1.15 (1.02-1.26) | 0.024 |
| Social functioning | 1.46 (1.37-1.56) | <0.001 | 1.09 (1.01-1.16) | 0.023 | 1.07 (0.96-1.21) | 0.24 |
| Physical role functioning | 1.61 (1.50-1.72) | <0.001 | 1.17 (1.08-1.27) | <0.001 | 1.17 (1.03-1.33) | 0.014 |
| Emotional role functioning | 1.57 (1.45-1.70) | <0.001 | 1.13 (1.03-1.23) | 0.008 | 1.13 (0.98-1.30) | 0.087 |
| Mental health | 1.37 (1.29-1.47) | <0.001 | 1.09 (1.01-1.17) | 0.024 | 1.07 (0.95-1.20) | 0.27 |
| Vitality | 1.67 (1.54-1.76) | <0.001 | 1.18 (1.10-1.26) | <0.001 | 1.18 (1.05-1.32) | 0.007 |
| Bodily pain | 1.54 (1.44-1.64) | <0.001 | 1.11 (1.04-1.21) | 0.002 | 1.08 (0.91-1.10) | 0.21 |
| General health | 1.92 (1.80-2.05) | <0.001 | 1.25 (1.16-1.34) | <0.001 | 1.21 (1.08-1.36) | 0.002 |
| NLR highest quintile | ||||||
| Physical functioning | 1.14 (1.11-1.18) | <0.001 | 1.04 (1.01-1.08) | 0.009 | 1.06 (1.00-1.11) | 0.043 |
| Social functioning | 1.12 (1.09-1.15) | <0.001 | 1.06 (1.03-1.10) | <0.001 | 1.10 (1.05-1.16) | <0.001 |
| Physical role functioning | 1.17 (1.13-1.21) | <0.001 | 1.07 (1.04-1.10) | <0.001 | 1.04 (0.98-1.10) | 0.17 |
| Emotional role functioning | 1.15 (1.11-1.20) | <0.001 | 1.08 (1.04-1.13) | <0.001 | 1.08 (1.00-1.15) | 0.033 |
| Mental health | 1.09 (1.06-1.12) | <0.001 | 1.06 (1.02-1.09) | 0.001 | 1.07 (1.01-1.12) | 0.016 |
| Vitality | 1.10 (1.07-1.14) | <0.001 | 1.03 (1.00-1.06) | 0.078 | 1.04 (0.99-1.10) | 0.14 |
| Bodily pain | 1.15 (1.12-1.19) | <0.001 | 1.06 (1.03-1.10) | <0.001 | 1.09 (1.03-1.15) | 0.002 |
| General health | 1.16 (1.13-1.19) | <0.001 | 1.06 (1.03-1.09) | <0.001 | 1.06 (1.01-1.12) | 0.025 |
Logistic regression analyses included body mass index, smoking status, alcohol use, number of medications used, presence of anemia, and mean corpuscular volume as covariates (model 1). Model 2 was additionally adjusted for hs-CRP, when available. A WBC count in the normal range and a NLR in the 2nd to 4th quintile were used as reference group.
CI = confidence interval; hs-CRP = high-sensitivity C-reactive protein; NLR = neutrophil to lymphocyte ratio; WBC = white blood cell.