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Presumed positive feedback loop in the malignant progression of GBM through TNIIIA2-derived signal transmission. (A) PDGF-B expression in p-TNIIIA2-stimulated GBM cells was evaluated by RT-PCR. (B) TN-C expression in PDGF-BB-stimulated GBM cells was evaluated by western blotting analysis. (C) Schematic illustration of the putative positive feedback loop underlying the acceleration of GBM aggressiveness.
