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. 2020 Dec 9;8:598205. doi: 10.3389/fcell.2020.598205

FIGURE 1.

FIGURE 1

Downregulation of PD-L1 Correlates with Poor Survival in EC. (A,B) Analysis of PD-L1 expression in human cancer tissues and normal tissues using the TCGA data retrieved from the UALCAN database (A), and FireBrowse database (B). CESC: human cervical cancer; UCEC: human endometrial cancer. (C,D) PD-L1 mRNA expression in EC samples and normal samples was analyzed using the Wanderer database (C) and ENCORI database (D). (E) IHC staining for PD-L1 in human cervical cancer tissues and EC tissues with the same antibody (CAB076385, the HPA website) showed that high levels of PD-L1 were present in primary cervical cancer tissues. In contrast, PD-L1 was negatively or weakly stained in most EC tissues. (F) The probability of overall survival in EC patients expressing high or low PD-L1 levels was assessed using the KM plotter database (upper) and the HPA database (bottom). Red indicates CESC (human cervical cancer) or UCEC (human endometrial cancer).