Table 1.
Overexpression of calcium-related proteins in human breast cancer patient samples. A list of differentially expressed calcium-related proteins in breast cancer patient tissue at the protein or transcript level is shown. Comparisons are made with respect to malignant vs. non-malignant tissue, tumor grade, and survival outcomes
| Protein | Comparison | Method | Reference | |
|---|---|---|---|---|
| Calcium Channels |
STIM1/2 STIM1 |
Malignant > adjacent High expression predicts poor survival |
IHC mRNA |
Miao et al. 2019 McAndrew et al. 2011 |
|
ORAI1 ORAI3 |
Correlated with basal subtype Malignant > Normal |
mRNA mRNA |
McAndrew et al. 2011 Faouzi et al. 2011 |
|
| RyR | Correlated with tumor grade | IHC | Abdul et al. 2008 | |
| IP3R2/3 | Malignant > normal | IHC/mRNA | Singh et al. 2017b | |
| MCU | Correlated with basal subtype | mRNA | Curry et al. 2013 | |
| P2X7 | Malignant > normal | Western blot | Tan et al. 2015 | |
| TRPA1 | Malignant > normal | IHC/mRNA | Takahashi et al. 2018 | |
|
TRPC1/C6 TRPC3/C6 TRPC6 TRPC7 |
Malignant > normal Malignant > normal Malignant > normal Malignant > adjacent |
IHC/mRNA mRNA IHC/mRNA mRNA |
Dhennin-Duthille et al. 2011 Aydar et al. 2009 Guilbert et al. 2008 Tsavaler et al. 2001 |
|
| TRPM7 |
Malignant > normal Malignant > normal High expression predicts poor survival Malignant > normal |
IHC/mRNA mRNA mRNA IHC/mRNA |
Guilbert et al. 2009 Meng et al. 2013 Middelbeek et al. 2012 Dhennin-Duthille et al. 2011 |
|
| TRPM8 |
Malignant > normal Malignant > adjacent Correlated with basal subtype Malignant > normal |
IHC Western blot/mRNA mRNA IHC/mRNA |
Chodon et al. 2010 Liu et al. 2014 Yapa et al. 2018 Dhennin-Duthille et al. 2011 |
|
| TRPV4 | Correlated with basal subtype | mRNA | Peters et al. 2017 | |
| TRPV6 |
Malignant > normal Correlated with basal subtype High expression predicts poor survival Malignant > normal |
mRNA mRNA mRNA IHC/mRNA |
Bolanz et al. 2008 Dhennin-Duthille et al. 2011/Peters et al. 2012 Peters et al. 2012 Dhennin-Duthille et al. 2011 |
|
| GPCRs | P2Y6 |
Correlated with basal subtype High expression predicts poor survival |
mRNA mRNA |
Azimi et al. 2016 Azimi et al. 2016 |
|
Calcium Pumps Calcium Effectors and Enzymes |
PMCA2 |
Correlated with basal subtype High expression predicts poor survival |
mRNA mRNA |
Peters et al. 2016/VanHouten et al. 2010 VanHouten et al. 2010 |
| SPCA2 |
Malignant > adjacent Correlated with basal subtype |
mRNA mRNA |
Feng et al. 2010 Grice et al. 2010 |
|
|
CREB CREB1 CREB1 CREB2 |
Malignant > adjacent Malignant > normal High expression predicts poor survival Malignant > normal |
mRNA IHC/mRNA mRNA IHC/Western blot |
Sofi et al. 2003 Chhabra et al. 2007 Chhabra et al. 2007 Fan et al. 2012 |
|
| CAMKII |
Malignant > adjacent High expression predicts poor survival |
IHC mRNA |
Chi et al. 2016 Chi et al. 2016 |
|
| NFAT2 | Malignant > normal | IHC | Quang et al. 2015 | |
| PKCα | High expression predicts poor survival | mRNA | Lonne et al. 2010 | |
| PKCζ |
Malignant > normal Malignant > normal |
IHC IHC/Western Blot |
Paul et al. 2015 Smalley et al. 2019 |
|
|
S100A6/A9/A11 S100A8/A9/A10/A11/A14 S100A11/A14 |
Malignant > normal Correlated with tumor grade High expression predicts poor survival |
IHC mRNA mRNA |
Cross et al. 2005 McKiernan et al. 2011 McKiernan et al. 2011 |