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Enterovirus 5’ m7G-cap independent translation via its IRES drives viral translation and a cytotoxic program unleashed by immediate early release of 2Apro. Simultaneously, vRNA signatures are detected by host cell dsRNA sensors that initiate the host innate antiviral response. The outcome of the infection is determined by the balance of viral, IRES-mediated translation vs. host sensing of incoming vRNA templates.
