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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Curr Opin Virol. 2020 Jun 30;44:16–25. doi: 10.1016/j.coviro.2020.05.004

Table 1:

Bunyavirus virulence factors as determined by reverse genetics

Family Virulence factors Function (s) Refs
Arenaviridae NP IFN antagonist [2,42]
Z IFN antagonist [2,42]
GPC Virus replication [42]
Peribunyaviridae NSs IFN antagonist [3032]
Phenuiviridae NSs Inhibition of host transcription, PKR degradation, and IFN antagonist [23,35,3839]
NSm Anti-apoptotic [23]