Figure 3. Dynamic chromatin organization across different stages of P. falciparum.
Telomere regions (black spheres) as well as inactive var genes (red spheres) are located within the repressive cluster at the periphery of the nucleus, while centromeres (green spheres) form a cluster on the opposite side. The active var gene is represented by a blue sphere. Throughout the life cycle, extensive remodeling of the chromatin occurs and provides essential modulation of gene expression during parasite development.