TABLE 2.
Patient demographics by treatment group compared to controls
| Variable | Treatment group | p-value | ||||
|---|---|---|---|---|---|---|
| S (n = 17) |
S+C (n = 11) |
HC (n = 18) |
Total (n = 46) |
|||
| Age – mean (SD) | 10.76 (4.02) | 12.18 (3.52) | 10.56 (2.23) | 11.02 (3.25) | 0.41 | |
| Age at Diagnosis – mean (SD) | 6.02 (3.57) | 3.52 (3.29) | NA | 5.04 (3.63) | 0.07 | |
| Sex | Male | 4 (24%) | 6 (55%) | 10 (56%) | 20 (43%) | 0.11 |
| Female | 13 (76%) | 5 (45%) | 8 (38%) | 26 (53%) | ||
| Handedness | Right | 14 (82%) | 10 (91%) | 17 (94%) | 41 (89%) | 0.78 |
| Left | 3 (18%) | 1 (9%) | 1 (5%) | 5 (11%) | ||
| Patient Race/ethnicity | White | 15 (88%) | 10 (91%) | 16 (89%) | 41 (89%) | Race – 0.84 |
| Non-Hispanic | 7 (41%) | 3 (27%) | 10 (63%) | 20 (43%) | Ethnicity – 0.11 | |
| Hispanic/Latino | 9 (53%) | 8 (73%) | 6 (33%) | 23 (50%) | ||
| Black/African American | 1 (6%) | 0 (0%) | 0 (0%) | 1 (2%) | ||
| Asian | 1 (6%) | 1 (9%) | 2 (11%) | 4 (9%) | ||
| Diagnosis | medulloblastoma | 0 (0%) | 7 (64%) | NA | 7 (25%) | 0.0001 |
| ependymoma | 0 (0%) | 1 (9%) | 1 (4%) | |||
| Astrocytoma | 2 (12%) | 0 (0%) | 2 (7%) | |||
| Pilocytic Astrocytoma | 14 (82%) | 2 (18%) | 16 (57%) | |||
| Other | 1 (6%) | 1 (9%) | 2 (7%) | |||
| Time Off Treatment (years) – mean (SD) | 4.47 (3.20) | 8.09 (4.71) | NA | 5.89 (4.19) | 0.02 | |
| Region of tumor location | Midline | 6 (35%) | 7 (64%) | NA | 13 (46%) | 0.18 |
| Left | 4 (24%) | 3 (27%) | 7 (25%) | |||
| Right | 7 (41%) | 1 (9%) | 8 (29%) | |||
| Hydrocephalus at diagnosis | Yes | 10 (59%) | 7 (64%) | NA | 17 (61%) | 0.75 |
| No | 5 (29%) | 2 (18%) | 7 (25%) | |||
| Unknown | 2 (12%) | 2 (18%) | 4 (14%) | |||
| Hydrocephalus severity | Mild | 3 (30%) | 2 (29%) | NA | 5 (29%) | 0.87 |
| Moderate | 6 (60%) | 3 (43%) | 9 (53%) | |||
| Severe | 0 (0%) | 1 (14%) | 1 (6%) | |||
| Unknown | 1 (10%) | 1 (14%) | 2 (12%) | |||
| VP shunt | Yes | 1 (6%) | 6 (55%) | NA | 7 (25%) | 0.002 |
| No | 16 (94%) | 5 (45%) | 21 (75%) | |||
| Bilingual | No | 10 (59%) | 4 (36%) | 10 (56%) | 24 (52%) | 0.82 |
| Yes | 5 (29%) | 5 (45%) | 6 (33%) | 16 (35%) | ||
| Missing | 2 (12%) | 2 (18%) | 2 (11%) | 6 (13%) | ||
| Annual Income | ≤ $39,999 | 6 (35%) | 4 (36%) | 7 (39%) | 17 (37%) | 0.80 |
| $40,000-$79,999 | 1 (6%) | 1 (9%) | 2 (11%) | 4 (9%) | ||
| ≥ $80,000 | 7 (41%) | 3 (27%) | 8 (44%) | 18 (39%) | ||
| Missing | 3 (18%) | 3 (27%) | 1 (6%) | 7 (15%) | ||
| Did mother attend college? | No | 7 (41%) | 5 (45%) | 8 (44%) | 20 (43%) | 0.12 |
| Yes - BS | 1 (6%) | 4 (36%) | 2 (11%) | 7 (15%) | ||
| Yes - Grad | 6 (35%) | 1 (9%) | 8 (44%) | 15 (33%) | ||
| Missing | 3 (18%) | 1 (9%) | 0 (0%) | 4 (9%) | ||
| Did father attend college? | No | 6 (35%) | 5 (45%) | 3 (17%) | 14 (30%) | 0.11 |
| Yes - BS | 4 (24%) | 4 (36%) | 9 (50%) | 17 (37%) | ||
| Yes - Grad | 3 (18%) | 1 (9%) | 6 (33%) | 10 (22%) | ||
| Missing | 4 (24%) | 1 (9%) | 0 (0%) | 5 (11%) | ||
Bold font indicates significant p-value (p ≤0.05)