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. Author manuscript; available in PMC: 2021 Dec 21.
Published in final edited form as: Curr Biol. 2020 Oct 15;30(24):4896–4909.e6. doi: 10.1016/j.cub.2020.09.045

Figure 6. Rdl-mediated inhibition gates encodings of weak noxious stimuli.

Figure 6.

(A) Confocal imaging showing endogenous Rdl (tagged by V5) expression pattern in LK neurons (labeled by GFP). The schematic drawing shows the design of the Rdl-stop-V5 knock-in flies and its use for labeling endogenous Rdl in specific neuron types. Arrows and arrowheads point at LK somas and their neurites within the PMC region, respectively.

(B-C) RNAi-mediated knockdown of Rdl (Rdl-IR) in LK neurons increased the activity levels of LK neurites within the PMC (B) and the probability of escape behaviors (C) only at low intensity of nociceptor stimulation (10−1 μW/mm2) but not at higher intensities. (B) Each dot represents a larva. N = 15 per genotype for each intensity group. Mann-Whitney U test. (C) N = 100 per genotype for each intensity group. Fisher’s exact test.

See also Figure S6 and Table S1.