Table 3:

Results from linear mixed models depicting the percent changes in CRH and reproductive hormone concentrations associated with an interquartile range increase in PAH metabolite concentrations over the study period.

	CRH			Estriol			Progesterone
	%Δ (95% CI)	P-Value		%Δ (95% CI)	P-Value		%Δ (95% CI)	P-Value
1-OH-NAP	14.0 (4.06, 24.9)	0.005		−0.33 (−6.93, 6.75)	0.925		1.67 (−3.93, 7.60)	0.568
2-OH-NAP	−6.36 (−15.3, 3.54)	0.202		−3.30 (−9.98, 3.87)	0.359		−2.23 (−7.85, 3.73)	0.456
1-OH-PYR	9.21 (−1.93, 21.6)	0.110		13.2 (4.73, 22.3)	0.002		8.11 (1.37, 15.3)	0.019
2-OH-FLU	15.3 (4.54, 27.1)	0.005		2.92 (−4.13, 10.5)	0.428		2.91 (−2.98, 9.16)	0.342
1-OH-PHE	24.3 (13.0, 36.7)	0.000		11.3 (3.94, 19.23	0.003		9.53 (3.47, 15.9)	0.002
Σ2,3-OH-PHE	18.1 (7.00, 30.4)	0.001		10.1 (2.47, 18.3)	0.009		4.52 (−1.55, 11.0)	0.149
	Progesterone/Estriol			Testosterone			SHBG
	%Δ (95% CI)	P-Value		%Δ (95% CI)	P-Value		%Δ (95% CI)	P-Value
1-OH-NAP	2.53 (−2.76, 8.11)	0.357		−17.2 (−25.4, −8.13)	0.000		−0.18 (−3.28, 3.02)	0.910
2-OH-NAP	0.76 (−4.74, 6.57)	0.792		7.30 (−4.66, 20.8)	0.244		−3.39 (−6.79, 0.13)	0.061
1-OH-PYR	−5.64 (−11.2, 0.27)	0.063		−12.4 (−22.6, −0.88)	0.037		4.00 (0.22, 7.94)	0.039
2-OH-FLU	−0.65 (−6.00, 5.01)	0.819		−14.0 (−23.1, −3.82)	0.009		0.11 (−3.22, 3.56)	0.947
1-OH-PHE	−2.67 (−7.81, 2.75)	0.329		−18.0 (−26.6, −8.28)	0.001		3.38 (−0.06, 6.93)	0.055
Σ2,3-OH-PHE	−5.60 (−10.8, −0.15)	0.046		−4.76 (−15.0, 6.67)	0.400		1.10 (−2.31, 4.62)	0.533

All models adjusted for continuous maternal age, categorical maternal education, categorical maternal exposure to environmental tobacco smoke, and specific gravity.