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Model of glymphatic fluid movement. Cerebrospinal fluid (CSF) enters the subarachnoid space, ultimately traveling down periarterial spaces. From there, the bulk flow of fluid causes CSF and interstitial fluid (ISF) mixing. The “dirty” ISF, containing waste and perhaps cytokines/inflammatory markers, exits the brain via the perivenous spaces. Graphic courtesy of Dan Xue. Color images are available online.
