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Differences between adult and pediatric MAFLD.
| Clinical Features | Children | Adults |
|---|---|---|
| Prevalence (4, 16) | 7.6% overall, and 34.2% obese | 24% overall, and 45–70% obese |
| Histology (17) | ||
| Steatosis |
Typically zone 1 |
Typically zone 3 |
| Inflammation | Mainly portal | Mainly lobular |
| Ballooning | Rale | Common |
| Fibrosis | Predominantly portal-periportal | Perisinusoidal chicken wire |
| Cirrhosis (18) | 1–2% | 5–10% |
| Prognosis marker (19) | Unknown (lack of long-term longitudinal studies) | Degree of fibrosis |
