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. 2020 Dec 22;11:6442. doi: 10.1038/s41467-020-20221-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Extracellular view of the superposition of D₂R_spi and D₂R_ris. The side chains of disulfide bridge, I183^45.51 and I184^45.52 are shown as sticks. Red arrows indicate the shift of helices in D₂R_ris with the distance relative to D₂R_spi. b Extracellular view of ECL1 and ECL2 of D₂R_spi, D₂R_ris, D₂R_hal and D₂R_bro. The side chains of the disulfide bridge, W100^23.50, I183^45.51, and I184^45.52 are shown as sticks. Surface representation of D₂R_spi (c) and D₂R_ris (d) viewed from the extracellular side. ECL1 and ECL2 are pink and yellow, respectively. e The EBP of D₂R_spi and the corresponding part of D₂R_ris, D₂R_hal and D₂R_bro. The side chains of W90^2.60 and F110^3.28 are shown as sticks. f Side view of the superposition of D₂R_spi, D₂R_ris, D₂R_hal and D₂R_bro around TM5 and ECL2. Red arrows indicate the shift of the extracellular half of TM5 in D₂R_ris and D₂R_hal relative to D₂R_spi. In (b), (e), and (f), D₂R_spi (green), D₂R_ris (cyan), D₂R_hal (purple), D₂R_bro (olive), spiperone (orange), risperidone (magenta), haloperidol (ivory), and bromocriptine (lightblue) are shown.