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. 2020 Dec 22;11:6435. doi: 10.1038/s41467-020-20143-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Concentration-dependent inhibition of βI-tryptase enzymatic activity in the presence of heparin by rabbit (rab) E104, rabbit-human chimeric (ch) E104 IgG1 and E104 IgG4. b Humanized E104.v1 and E104.v2 IgG1 show concentration-dependent inhibition of βI-tryptase enzymatic activity, but E104.v1 loses its inhibitory activity at higher concentrations (hook effect). c Primary human bronchial smooth muscle cell (BSMC) proliferation stimulated by βI-tryptase, which is inhibited by anti-tryptase humanized E104.v2 IgG4 in a concentration-dependent manner. d Primary human smooth muscle cell contraction is induced by βI-tryptase, which is inhibited by humanized E104.v2 IgG4. Data is represented as mean ± s.d. (n = 3 biologically independent experiments; a, b and n = 4 biologically independent experiments; c, d). Graphs were created using Kaleidagraph v4.1.3. Source data are provided as a Source Data file.