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. 2020 Dec 22;11:6435. doi: 10.1038/s41467-020-20143-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Cartoon representation of IgG and sequence comparison of the hinge regions of human IgG1, 2, and 4. b Cartoon depiction of Fab wingspans for IgG1, 2, and 4. IgG1 and 4 exhibit wingspans between 120° and 180° (Y to T shape) while IgG2 has a narrower wingspan around 120° (predominantly Y shape). c Inhibition of β-tryptase activity by E104.v2 IgG1 having extended (+G, +GG, +GGS or +(GGS)₃) and shortened (-H, -TH, -KTH) hinges. d, Inhibition of β-tryptase activity by E104.v2 IgG1 having different flexibilities (G5 vs. P5) or constraints (C, CC). Data is represented as mean ± s.d. (n = 3 biologically independent experiments). Graphs were created using Kaleidagraph v4.1.3 and images were created in Adobe Illustrator v16. Source data are provided as a Source Data file.